Pfizer China Launches Ecnoglutide – World’s First cAMP-Biased GLP-1 Drug
Jun 01,2026
On May 31, 2026,Pfizer China has launched Xianweiyin® (Ecnoglutide Injection) , the world’s first cAMP-biased GLP-1 receptor agonist, approved in China for type 2 diabetes and chronic weight management.
Phase III SLIMMER trial (48 weeks, n=664, overweight/obesity):
- 15.4% mean weight loss at 2.4 mg
- 92.8% achieved ≥5% weight loss
- GI-related discontinuation rate: only 0.6% – significantly lower than traditional GLP-1 drugs (>1%)
- Mean waist circumference reduction: 12.8 cm
- No traditional weight-loss plateau observed
Mechanism advantage:
Based on Nobel Prize-winning GPCR research, Ecnoglutide preferentially activates metabolic pathways for weight loss and glucose control while reducing gastrointestinal side effects.
Origin & pipeline:
Discovered by Sciwind Biosciences (Hangzhou). Pfizer holds exclusive commercial rights in mainland China in a deal valued up to $495 million. An oral formulation is also in global development.
Remark: This content is AI-generated and for reference only. It is compiled from online sources. Please refer to official information for accuracy.
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